Okay, the picture is coming into focus: you built the stud walls and ceiling not necessarily for isolation, just as space to run electrical and acoustic insulation. The penetrations are the door and an 8" hole. I'm assuming the hole is down low for plumbing (drainage) and electrical. I would love to see a picture of it.
Is it a two story house (main floor and concrete basement)? The garage is on the main floor on top of the HT room?
If it is two story is the plumbing connected to the upper living space at all? Is it just for drainage and the upper living space sewage a completely different system? If it is separate I would go to the little extra trouble to make it a real room within a room environment.
HVAC sounds good except for one detail: You have a movie marathon on a cold winter's day and spend many hours in the room with 3 or 4 people. The room is completely sealed. Have you thought about fresh air ventilation? Humidity? It's something to seriously think about.
Without digging into HVAC and just going with what you have, first, I would buy Rod Gervais' book: https://www.amazon.com/Home-Recording-S ... 143545717X Well worth the $30. Written in laymen's terms and covers all the basic details to give you a better handle on things.
No blown in densely packed celluose insulation. It settles and doesn't have any acoustic advantage.
No foam. People are finding it may have some health issues and it doesn't do anything for sound. It's good for thermal but not acoustic.
Without going overboard on cost, for isolation here's what I would do: (this incorporates some of what Tom said earlier)
Seal the 8" hole. Without seeing it I'm not sure what to tell you except that Mass is your friend. Don't use foam because it won't stop the sound very effectively (low mass). If you can inject concrete sealant like this: https://www.lowes.com/pd/Sika-10-1-oz-L ... /999977050 or trowel in concrete etc. that might be best. Yes, sound will travel through the pipe but if it's not connected to the living space it's not such a big deal. Does it penetrate the stud wall? If so that's a real killer of isolation. I'll assume it doesn't.
If you can lift the stud assembly a little at a time and put thin rubber strips underneath and caulk with the real stretchy caulk (Sashco Big Stretch, etc.) to completely seal the perimeter that would help a little. Not a huge deal with the concrete floor but it would help some.
Then I would consider the wiring (and equipment if it's noisy fans, etc.). One penetration is best if possible. I'm assuming you have lights on a circuit and then floor outlets. You already have the light boxes in I see but I'm telling you what I would do

The step after taking care of the hole and wiring and HVAC is to put pink insulation in the studs, completely filling all spaces in the walls and ceiling. For this step pink insulation is just as effective as mineral wool or celluose. Then put a layer of 5/8 drywall up on all the walls AND ceiling. Keep the drywall 1/4" off the floor all around. Put stretchy caulk/sealant on the studs before hanging the drywall. Caulk all the edges of the drywall with sealant. Use backer rod where needed. Other than the door opening it needs to be completely sealed. The penetration for electrical should be as tight as possible. If you have multiple penetrations with outlet boxes caulk all of them. (I would run surface wiring and hang a cloud with lighting built in so I could only have one electrical penetration through the wall)
Then put up a second layer of 1/2" drywall on all the walls and ceiling. Before placing the drywall I would liberally trowel carpet adhesive on all surfaces as I go: https://www.homedepot.com/p/Roberts-4-G ... /202261817 This adhesive stays flexible and helps decouple the layers (lowering the resonance). Studio builds with big budgets use dedicated "green glue" but the Roberts has very similar properties and is much cheaper. The second layer should alternate to the first layer- for instance if the first sheets were laid horizontally hang the second layer vertically. Overlap the inside edges. Caulk with sealant all the joints.
At this point you shouldn't have spent too much. Just an extra layer of drywall and caulk should be the biggest expense.
If you get Rod's book it goes into excellent detail on the door. Again, it doesn't have to be expensive but it has to have a lot of mass and be acoustically separated from the inner wall. If you don't get the book I can help walk you through it.
Okay, a lot so far. I need to get some work done. The basic idea is that the inner room needs to be completely separated from the outer room. The floor of course won't be but it's not a big deal. ~ 10hz and down.
You may be thinking, well, what about the acoustics of the room? Don't worry, you've already addressed some of the acoustics, because the walls and ceiling of the inner room has their own resonances at slightly higher frequencies (still in the bass range). They will flex both fundamentally and in harmonics when the bass is booming and absorb (convert) some of that energy. Some of the slightly higher frequencies will penetrate the drywall, be "slowed down" some by the insulation, bounce off the concrete walls, go back through the insulation and double layer of drywall and dribble back into the room. All the while being converted from audio energy to heat. Yes, there's bass traps and upper frequencies to deal with but not too bad.
I'll be glad to give more detail as needed. All kinds of fun stuff. If you really want to dig in buy a cheap sound level meter, a measurement mic and appropriate software and make it an adventure. Oh, maybe go with Dayton Audio DSP-408 for your front L/R/C/subwoofer setup. It's a ton of fun.
Alright, I'll shut up. Gotta finish some work on the roof of my studio....