The setup:
Yamaha MC Series mixer
Behringer DEQ2496
Older version of this 4-channel Carvin power amp: http://www.carvinguitars.com/products/s ... t=DCM2004L
J10s
Of course, my immediate suspicion is the power amp. I ran the mains mono on channel 1 starting out. After the first episode I switched the mains between songs to channel 4 on the amp and it happened again once more before it finally stabilized.
One other thing I've noticed about the amp is that the power doesn't seem the same on every channel even though they're rated the same: 1 seems hotter than the rest, 2 and 4 are about the same and 3 less. I just thought of something: maybe there's a bridging button on (but I think it bridges channels 2 and 3)?
These symptoms certainly point to a possible amp problem, but do the symptoms possibly point to anything else? Could it be the DEQ or Yamaha board? Cables (I have decent cordage)? Could it be a power supply issue (but I've had this happen at multiple venues)?
I am inclined to kick the whole rack to the curb and buy some kind of decent all-in-one powered mixer to make troubleshooting a little simpler. You know, now that I think of it, mixing your own sound is kind of a crazy proposition.

Any thoughts on this much appreciated.